Abstract The emergence of carbapenem-resistant Gram-negative pathogens poses a serious threat to public health worldwide. In particular, the increasing prevalence of carbapenem-resistant Klebsiella pneumoniae is a major source of concern. K. pneumoniae carbapenemases (KPCs) and carbapenemases of the oxacillinase-48 (OXA-48) type have been reported worldwide. New Delhi metallo-β-lactamase (NDM) carbapenemases were originally identified in Sweden in 2008 and have…
Category: Klebsiella
Author: Taha Rashid Specialty: Immunology, Internal Medicine Institution: Analytical Sciences Group, Kings College London Address: London, SE1 9NN, United Kingdom Author: Alan Ebringer Specialty: Immunology, Internal Medicine Institution: Analytical Sciences Group, Kings College London Address: London, SE1 9NN, United Kingdom Abstract: Ankylosing spondylitis (AS) and Crohn’s disease (CD), especially when associated with spondylitis are interrelated conditions included within the categories of spondyloarthropathic…
Ebringer A, Wilson C. Abstract The majority of ankylosing spondylitis (AS) patients not only possess HLA-B27, but during active phases of the disease have elevated levels of total serum IgA, suggesting that a microbe from the bowel flora is acting across the gut mucosa. Biochemical studies have revealed that Klebsiella bacteria, not only possess 2…
Li JQ, Tang CQ, Wang H, Ji SZ, Lü KY, Xiao SC, Deng AM, Huang Y, Xia ZF Abstract OBJECTIVE: To evaluate the impact of extended-spectrum β-lactamase (ESBL) on clinical outcome and medical cost in patients with bloodstream infection (BSI) due to Klebsiella pneumoniae. METHODS: A retrospective study was conducted in patients admitted into Changhai Hospital between January 2013 and…
Thaden JT, Pogue JM, Kaye KS Abstract Antimicrobial resistance has been identified by the World Health Organization as “one of the three greatest threats to human health.” Gram negative bacteria in particular drive this alarming trend. Carbapenem-resistant Enterobacteriaceae (CRE) such as Escherichia coli, Klebsiella pneumoniae, and Enterobacter species are of particular importance as they are associated…
Bacteremia por Klebsiella Ozaenae y por Klebsiella Oxytoca a propósito de cinco pacientes. Ricardo Boza, Marí de los Angeles San Román. Artículo (bastante antigüo) encontrado en la biblioteca nacional de Costa Rica. Lo agrego porque es de lo poco que he encontrado en Internet sobre estas dos variantes de Klebsiella. En los cinco casos se usó gentamicina, con…
Rashid T, Ebringer A, Wilson C. Abstract Ankylosing spondylitis (AS) is a world-wide chronic inflammatory disease of the axial skeleton most likely caused by a microbial factor in genetically susceptible individuals. Over the last 40 years extensive data has been produced which shows that the majority of patients with AS possess the HLA-B27 genetic marker. Significantly…
Zhanel GG, Wiebe R, Dilay L, Thomson K, Rubinstein E, Hoban DJ, Noreddin AM, Karlowsky JA. The carbapenems are beta-lactam antimicrobial agents with an exceptionally broad spectrum of activity. Older carbapenems, such as imipenem, were often susceptible to degradation by the enzyme dehydropeptidase-1 (DHP-1) located in renal tubules and required co-administration with a DHP-1 inhibitor such as cilastatin. Later additions to…