Abstract The emergence of carbapenem-resistant Gram-negative pathogens poses a serious threat to public health worldwide. In particular, the increasing prevalence of carbapenem-resistant Klebsiella pneumoniae is a major source of concern. K. pneumoniae carbapenemases (KPCs) and carbapenemases of the oxacillinase-48 (OXA-48) type have been reported worldwide. New Delhi metallo-β-lactamase (NDM) carbapenemases were originally identified in Sweden in 2008 and have…
Author: davidzamorano
Author: Taha Rashid Specialty: Immunology, Internal Medicine Institution: Analytical Sciences Group, Kings College London Address: London, SE1 9NN, United Kingdom Author: Alan Ebringer Specialty: Immunology, Internal Medicine Institution: Analytical Sciences Group, Kings College London Address: London, SE1 9NN, United Kingdom Abstract: Ankylosing spondylitis (AS) and Crohn’s disease (CD), especially when associated with spondylitis are interrelated conditions included within the categories of spondyloarthropathic…
Sokol H, Pigneur B, Watterlot L, Lakhdari O, Bermúdez-Humarán LG, Gratadoux JJ, Blugeon S, Bridonneau C, Furet JP, Corthier G, Grangette C, Vasquez N, Pochart P, Trugnan G, Thomas G, Blottière HM, Doré J, Marteau P, Seksik P, Langella P. Abstract A decrease in the abundance and biodiversity of intestinal bacteria within the dominant phylum Firmicutes has been observed repeatedly in Crohn disease (CD) patients. In this study, we determined the composition of…
Ebringer A, Wilson C. Abstract The majority of ankylosing spondylitis (AS) patients not only possess HLA-B27, but during active phases of the disease have elevated levels of total serum IgA, suggesting that a microbe from the bowel flora is acting across the gut mucosa. Biochemical studies have revealed that Klebsiella bacteria, not only possess 2…
Li JQ, Tang CQ, Wang H, Ji SZ, Lü KY, Xiao SC, Deng AM, Huang Y, Xia ZF Abstract OBJECTIVE: To evaluate the impact of extended-spectrum β-lactamase (ESBL) on clinical outcome and medical cost in patients with bloodstream infection (BSI) due to Klebsiella pneumoniae. METHODS: A retrospective study was conducted in patients admitted into Changhai Hospital between January 2013 and…
Thaden JT, Pogue JM, Kaye KS Abstract Antimicrobial resistance has been identified by the World Health Organization as “one of the three greatest threats to human health.” Gram negative bacteria in particular drive this alarming trend. Carbapenem-resistant Enterobacteriaceae (CRE) such as Escherichia coli, Klebsiella pneumoniae, and Enterobacter species are of particular importance as they are associated…
Strawbridge S, Nailor MD Abstract BACKGROUND: High doses of β-lactam antibiotics have been advocated for acute pulmonary exacerbations caused by Pseudomonas aeruginosa in patients with cystic fibrosis (CF) secondary to high minimum inhibitory concentrations (MIC) of the infecting organisms. Some β-lactam antibiotics have increased elimination in CF patients. This case series examines the safety…
Nicolau DP Abstract The purpose of this review is to assess the relative strengths and weaknesses of individual members of the carbapenem class of antibiotics. Clinical trials and review articles were identified from a Medline search (1979 – July 2006), in addition to, reference citations from identified publications, abstracts from the Interscience Conferences on…
Bacteremia por Klebsiella Ozaenae y por Klebsiella Oxytoca a propósito de cinco pacientes. Ricardo Boza, Marí de los Angeles San Román. Artículo (bastante antigüo) encontrado en la biblioteca nacional de Costa Rica. Lo agrego porque es de lo poco que he encontrado en Internet sobre estas dos variantes de Klebsiella. En los cinco casos se usó gentamicina, con…
Rashid T, Ebringer A, Wilson C. Abstract Ankylosing spondylitis (AS) is a world-wide chronic inflammatory disease of the axial skeleton most likely caused by a microbial factor in genetically susceptible individuals. Over the last 40 years extensive data has been produced which shows that the majority of patients with AS possess the HLA-B27 genetic marker. Significantly…