Artículos recientes
Global Dissemination of Carbapenemase-Producing Klebsiella pneumoniae: Epidemiology, Genetic Context, Treatment Options, and Detection Methods
Abstract The emergence of carbapenem-resistant Gram-negative pathogens poses a serious threat to public health worldwide. In particular, the increasing prevalence of carbapenem-resistant Klebsiella pneumoniae is a major source of concern. K. pneumoniae carbapenemases (KPCs) and carbapenemases of the oxacillinase-48 (OXA-48) type have been reported worldwide. New Delhi metallo-β-lactamase (NDM) carbapenemases were originally identified in Sweden in 2008 and have…
Gut-mediated and HLA-B27-associated Arthritis: An Emphasis on Ankylosing Spondylitis and Crohn’s Disease with a Proposal for the Use of New Treatment
Author: Taha Rashid Specialty: Immunology, Internal Medicine Institution: Analytical Sciences Group, Kings College London Address: London, SE1 9NN, United Kingdom Author: Alan Ebringer Specialty: Immunology, Internal Medicine Institution: Analytical Sciences Group, Kings College London Address: London, SE1 9NN, United Kingdom Abstract: Ankylosing spondylitis (AS) and Crohn’s disease (CD), especially when associated with spondylitis are interrelated conditions included within the categories of spondyloarthropathic…
Faecalibacterium prausnitzii is an anti-inflammatory commensal bacterium identified by gut microbiota analysis of Crohn disease patients
Sokol H, Pigneur B, Watterlot L, Lakhdari O, Bermúdez-Humarán LG, Gratadoux JJ, Blugeon S, Bridonneau C, Furet JP, Corthier G, Grangette C, Vasquez N, Pochart P, Trugnan G, Thomas G, Blottière HM, Doré J, Marteau P, Seksik P, Langella P. Abstract A decrease in the abundance and biodiversity of intestinal bacteria within the dominant phylum Firmicutes has been observed repeatedly in Crohn disease (CD) patients. In this study, we determined the composition of…
The use of a low starch diet in the treatment of patients suffering from ankylosing spondylitis
Ebringer A, Wilson C. Abstract The majority of ankylosing spondylitis (AS) patients not only possess HLA-B27, but during active phases of the disease have elevated levels of total serum IgA, suggesting that a microbe from the bowel flora is acting across the gut mucosa. Biochemical studies have revealed that Klebsiella bacteria, not only possess 2…
Impact of extended-spectrum β-lactamase on clinical outcome and medical cost in patients with bloodstream infection due to Klebsiella pneumoniae
Li JQ, Tang CQ, Wang H, Ji SZ, Lü KY, Xiao SC, Deng AM, Huang Y, Xia ZF Abstract OBJECTIVE: To evaluate the impact of extended-spectrum β-lactamase (ESBL) on clinical outcome and medical cost in patients with bloodstream infection (BSI) due to Klebsiella pneumoniae. METHODS: A retrospective study was conducted in patients admitted into Changhai Hospital between January 2013 and…
Role of Newer and Re-emerging Older Agents in the Treatment of Infections Caused by Carbapenem-Resistant Enterobacteriaceae
Thaden JT, Pogue JM, Kaye KS Abstract Antimicrobial resistance has been identified by the World Health Organization as “one of the three greatest threats to human health.” Gram negative bacteria in particular drive this alarming trend. Carbapenem-resistant Enterobacteriaceae (CRE) such as Escherichia coli, Klebsiella pneumoniae, and Enterobacter species are of particular importance as they are associated…
Safety of high-dose doripenem in adult patients with cystic fibrosis
Strawbridge S, Nailor MD Abstract BACKGROUND: High doses of β-lactam antibiotics have been advocated for acute pulmonary exacerbations caused by Pseudomonas aeruginosa in patients with cystic fibrosis (CF) secondary to high minimum inhibitory concentrations (MIC) of the infecting organisms. Some β-lactam antibiotics have increased elimination in CF patients. This case series examines the safety…
Carbapenems: a potent class of antibiotics (2008)
Nicolau DP Abstract The purpose of this review is to assess the relative strengths and weaknesses of individual members of the carbapenem class of antibiotics. Clinical trials and review articles were identified from a Medline search (1979 – July 2006), in addition to, reference citations from identified publications, abstracts from the Interscience Conferences on…
5 casos de Klebsiella Ozaenae y Oxytoca. (Costa Rica, 1985)
Bacteremia por Klebsiella Ozaenae y por Klebsiella Oxytoca a propósito de cinco pacientes. Ricardo Boza, Marí de los Angeles San Román. Artículo (bastante antigüo) encontrado en la biblioteca nacional de Costa Rica. Lo agrego porque es de lo poco que he encontrado en Internet sobre estas dos variantes de Klebsiella. En los cinco casos se usó gentamicina, con…
The link between Klebsiella and ankylosing spondylitis in worldwide geographical locations
Rashid T, Ebringer A, Wilson C. Abstract Ankylosing spondylitis (AS) is a world-wide chronic inflammatory disease of the axial skeleton most likely caused by a microbial factor in genetically susceptible individuals. Over the last 40 years extensive data has been produced which shows that the majority of patients with AS possess the HLA-B27 genetic marker. Significantly…
Comparative review of the carbapenems
Zhanel GG, Wiebe R, Dilay L, Thomson K, Rubinstein E, Hoban DJ, Noreddin AM, Karlowsky JA. The carbapenems are beta-lactam antimicrobial agents with an exceptionally broad spectrum of activity. Older carbapenems, such as imipenem, were often susceptible to degradation by the enzyme dehydropeptidase-1 (DHP-1) located in renal tubules and required co-administration with a DHP-1 inhibitor such as cilastatin. Later additions to…
The potential of selected South African plants with anti-Klebsiella activity for the treatment and prevention of ankylosing spondylitis.
Cock IE, van Vuuren SF A wide variety of herbal remedies are used in traditional African medicine to treat inflammatory disorders, including some autoimmune diseases. Thirty-four extracts from 13 South African plant species traditionally used for the treatment of inflammation were investigated for their ability to control a microbial trigger for ankylosing spondylitis (Klebsiella pneumoniae). Twenty-six of the…